N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate

Base Information

• Chemical Name: N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate
• CAS No.: 1273319-38-2
• Molecular Formula: C₆H₈O₇*C₂₂H₂₀F₃N
• Molecular Weight: 547.528
• Mol file: 1273319-38-2.mol

Synonyms:N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate

Chemical Property of N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate

There total 11 articles about N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.1%

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride (1207533-91-2) + citric acid (77-92-9,906507-37-7) → N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate (1273319-38-2)

Guidance literature:

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride; With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 0.5h;

citric acid; In ethanol; Reflux;

Reference yield:

1-<3-(trifluoromethyl)phenyl>prop-2-en-1-ol (154309-48-5) → N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate (1273319-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 5 °C

2.1: potassium carbonate / acetonitrile / 12 h / 20 - 85 °C

2.2: 50 - 60 °C / pH 0.1 - 0.5

3.1: sodium hydrogencarbonate / ethyl acetate; water / 0.5 h / 20 °C

3.2: Reflux

With thionyl chloride; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-Trifluoromethylbenzaldehyde (454-89-7) → N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate (1273319-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 5 °C

3.1: potassium carbonate / acetonitrile / 12 h / 20 - 85 °C

3.2: 50 - 60 °C / pH 0.1 - 0.5

4.1: sodium hydrogencarbonate / ethyl acetate; water / 0.5 h / 20 °C

4.2: Reflux

With thionyl chloride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3-Trifluoromethylbenzaldehyde

(R)-1-(1-Naphthyl)ethylamine

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride

citric acid