(R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate

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Chemical Name:(R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate
CAS No.:1146434-43-6
Molecular Formula:C₃₈H₄₆N₂O₇S₃
Molecular Weight:738.99
Hs Code.:

Synonyms:(R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate

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Chemical Property of (R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate

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Technology Process of (R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate

There total 1 articles about (R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146434-50-5
C₁₂H₂₂N₂O₅S₂

: C₂₆H₂₆O₃S

: 1146434-43-6
(R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol900436f

Reference yield: 66.0%

: 1146434-43-6
(R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate

: 1146434-31-2
(3S,4R)-4-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tritylthio)propanamido)-5-methyl-3-(triisopropylsilyloxy)hexanoic acid

: 1146434-44-7
(3S,4R)-((S,E)-1-((R)-1-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yloxy)-1-oxopropan-2-ylamino)-1-oxo-7-(tritylthio)hept-4-en-3-yl) 4-((S)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-3-(tritylthio)propanamido)-5-methyl-3-(triisopropylsilyloxy)hexanoate

Guidance literature:: (3S,4R)-4-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tritylthio)propanamido)-5-methyl-3-(triisopropylsilyloxy)hexanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; for 0.333333h; Inert atmosphere;

(R)-((4R,5R)-5-(2-(2-methoxyethylamino)-2-oxoethoxy)-1,2-dithian-4-yl) 2-((S,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)propanoate; With dmap; In tetrahydrofuran; at 20 ℃; for 15.5h; Inert atmosphere;
DOI:10.1021/ol900436f