3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

Base Information

Chemical Name:3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine
CAS No.:1455036-08-4
Molecular Formula:C₂₄H₂₃FN₄O
Molecular Weight:402.471
Hs Code.:

Synonyms:3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

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Chemical Property of 3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

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Technology Process of 3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

There total 10 articles about 3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 702-24-9
4-methoxy-N-methylbenzylamine

: 1455035-79-6
5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoroaniline

: 1455036-08-4
3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 170 - 185 ℃; Inert atmosphere;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1455036-08-4
3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / ethanol / 1 h / 60 °C

6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 170 - 185 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1391740-89-8
ethyl 6-chloro-4-[(4-methoxyphenyl)methylamino]pyridine-3-carboxylate

: 1455036-08-4
3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / 50 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane / 20 °C

4: potassium hydroxide / ethanol / 1 h / 60 °C

5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 170 - 185 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;