[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate

Base Information

• Chemical Name: [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate
• CAS No.: 306296-86-6
• Molecular Formula: C₁₀H₁₁F₃O₃S
• Molecular Weight: 268.257
• Mol file: 306296-86-6.mol

Synonyms:[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate

Chemical Property of [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate

There total 2 articles about [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanesulfonyl chloride (124-63-0) + (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (1737-26-4,68120-43-4,99493-93-3,76155-79-8) → [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate (306296-86-6)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; cooling;

DOI:10.1021/jm0155401

Reference yield:

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate (306296-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 2M borane-methyl sulfide complex / (S)-2-methyl oxaborolidine / tetrahydrofuran / 0.25 h / cooling

2: 96 percent / Et₃N / CH₂Cl₂ / 1 h / cooling

With dimethylsulfide borane complex; triethylamine; 2-methyl oxaborolidine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0155401

Reference yield: 52.0%

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) + [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate (306296-86-6) → (S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (306296-88-8) + 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine (306296-87-7)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; In acetonitrile; for 16h; Heating / reflux;

upstream raw materials:

methanesulfonyl chloride

(R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol

1-(4-trifluoromethylphenyl)ethanone

Downstream raw materials:

(S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine

(S)-2-Methyl-1-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

tert-butyl 4-methyl-4-((S)-3-methyl-4-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)piperidine-1-carboxylate