1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine

Base Information

• Chemical Name: 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine
• CAS No.: 306296-87-7
• Molecular Formula: C₁₉H₂₇F₃N₂O₂
• Molecular Weight: 372.431

Synonyms:1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine

Chemical Property of 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine

Chemical Property:

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Technology Process of 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine

There total 7 articles about 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate + (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) → (S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (306296-88-8) + 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine (306296-87-7)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; In acetonitrile; for 16h; Heating / reflux;

Reference yield: 52.0%

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) + [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate (306296-86-6) → (S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (306296-88-8) + 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine (306296-87-7)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; In acetonitrile; for 16h; Heating / reflux;

Reference yield:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) + [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate (306296-86-6) → 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine (306296-87-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 - 90 ℃; for 16.5h; Product distribution / selectivity;

upstream raw materials:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate

N-(t-butoxycarbonyloxy)-phthalimide

1-(4-trifluoromethylphenyl)ethanone

Downstream raw materials:

(S)-2-Methyl-1-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

Sch 350634

Sch 350581

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