1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine
• CAS No.: 1237535-89-5
• Molecular Formula: C₁₀H₁₁BrF₃N
• Molecular Weight: 282.103
• Mol file: 1237535-89-5.mol

Synonyms:1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine

Chemical Property of 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine

There total 4 articles about 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1‐bromo‐3‐(bromomethyl)‐5‐(trifluoromethyl)benzene (954123-46-7) + dimethyl amine (124-40-3) → 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine (1237535-89-5)

Guidance literature:

In tetrahydrofuran; for 0.166667h; Inert atmosphere;

Reference yield: 74.0%

3-bromo-5-(trifluoromethyl)benzaldehyde (477535-41-4) + dimethyl amine (124-40-3) → 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine (1237535-89-5)

Guidance literature:

3-bromo-5-(trifluoromethyl)benzaldehyde; dimethyl amine; In tetrahydrofuran; dichloromethane; at 20 ℃;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

Reference yield: 74.0%

3-bromo-5-(trifluoromethyl)benzaldehyde (477535-41-4) → 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine (1237535-89-5)

Guidance literature:

3-bromo-5-(trifluoromethyl)benzaldehyde; With dimethyl amine; In tetrahydrofuran; dichloromethane; ethyl acetate; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 3h;

upstream raw materials:

3-bromo-5-(trifluoromethyl)benzaldehyde

dimethyl amine

1‐bromo‐3‐(bromomethyl)‐5‐(trifluoromethyl)benzene

(3‐bromo‐5‐(trifluoromethyl)phenyl)methanol

Downstream raw materials:

3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

3-((dimethylamino)methyl)-5-(trifluoromethyl)benzoic acid hydrochloride

3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzaldehyde

3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoic acid