2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester
CAS No.:171889-27-3
Molecular Formula:C₂₂H₃₂N₄O₃
Molecular Weight:400.521
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

There total 5 articles about 2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 171889-26-2
2,2-Dimethyl-propionic acid (S)-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-3-hydroxy-propyl ester

: 171889-27-3
2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

Guidance literature:: With sodium azide; carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jm960495w

Reference yield:

: 3282-30-2
pivaloyl chloride

: 171889-27-3
2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridine / 1.5 h / 0 °C

2: 91 percent / NaN₃, Ph₃P, CBr₄ / dimethylformamide / 3 h / Ambient temperature

With pyridine; sodium azide; carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1021/jm960495w

Reference yield:

: 172016-00-1
(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 171889-27-3
2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LiHMDS / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 2 h

2: 96 percent / NaBH₄ / methanol / 1 h / Heating

3: 88 percent / pyridine / 1.5 h / 0 °C

4: 91 percent / NaN₃, Ph₃P, CBr₄ / dimethylformamide / 3 h / Ambient temperature

5: 99 percent / MeONa, MeOH / 15 h / Ambient temperature

6: 99 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

7: 85 percent / ethanol / 15 h / Ambient temperature

With pyridine; methanol; dmap; sodium tetrahydroborate; sodium azide; carbon tetrabromide; sodium methylate; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960495w