2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

Base Information

Chemical Name:2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide
CAS No.:437655-90-8
Molecular Formula:C₂₂H₂₀N₄O₅
Molecular Weight:420.425
Hs Code.:

Synonyms:2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

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Chemical Property of 2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

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Technology Process of 2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

There total 8 articles about 2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 437655-88-4
2-(acetyloxy)-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

: 437655-90-8
2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 0.5h;
DOI:10.1021/ol020073i

Reference yield:

: 437655-86-2
2-(acetyloxy)-N-(2-bromophenyl)-N-methylacetamide

: 437655-90-8
2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Pd(PPh₃)2Cl₂ / dioxane / 18 h / 100 °C

2: 64 percent / NBS / tetrahydrofuran; H₂O / 0.25 h / 20 °C

3: NaN₃ / acetone; H₂O / 0.17 h / 50 °C

4: 95 percent / PPh₃ / dioxane / 0.25 h / 100 °C

5: 95 percent / LiOH*H₂O / methanol; H₂O / 0.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; N-Bromosuccinimide; sodium azide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetone;
DOI:10.1021/jm0105777

Reference yield:

: 437655-87-3
2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide

: 437655-90-8
2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / NBS / tetrahydrofuran; H₂O / 0.25 h / 20 °C

2: NaN₃ / acetone; H₂O / 0.17 h / 50 °C

3: 95 percent / PPh₃ / dioxane / 0.25 h / 100 °C

4: 95 percent / LiOH*H₂O / methanol; H₂O / 0.5 h / 20 °C

With lithium hydroxide; N-Bromosuccinimide; sodium azide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetone;
DOI:10.1021/jm0105777