2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide

Base Information

• Chemical Name: 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide
• CAS No.: 437655-87-3
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 437655-87-3.mol

Synonyms:2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide

Chemical Property of 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide

There total 3 articles about 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tributyl(1-ethoxyvinyl)stannane (97674-02-7) + 2-(acetyloxy)-N-(2-bromophenyl)-N-methylacetamide (437655-86-2) → 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide (437655-87-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 100 ℃; for 18h;

DOI:10.1021/ol020073i

Reference yield:

2-bromoaniline (615-36-1) → 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide (437655-87-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 2 h / 20 °C

2.1: dimethylformamide / 0.25 h

2.2: 100 percent / dimethylformamide / 1 h / 20 °C

3.1: 85 percent / Pd(PPh₃)2Cl₂ / dioxane / 18 h / 100 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0105777

Reference yield:

acetic acid (2-bromo-phenylcarbamoyl)-methyl ester (901335-15-7) → 2-(acetyloxy)-N-[2-(1-ethoxyethenyl)phenyl]-N-methylacetamide (437655-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylformamide / 0.25 h

1.2: 100 percent / dimethylformamide / 1 h / 20 °C

2.1: 85 percent / Pd(PPh₃)2Cl₂ / dioxane / 18 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm0105777

upstream raw materials:

tributyl(1-ethoxyvinyl)stannane

2-(acetyloxy)-N-(2-bromophenyl)-N-methylacetamide

2-bromoaniline

acetic acid (2-bromo-phenylcarbamoyl)-methyl ester

Downstream raw materials:

2-(acetyloxy)-N-[2-(2-bromoacetyl)phenyl]-N-methylacetamide

methanesulfonic acid ({2-[2-(3-methoxy-4-oxazol-5-yl-phenylamino)-oxazol-5-yl]-phenyl}-methyl-carbamoyl)-methyl ester

2-(acetyloxy)-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide

2-hydroxy-N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methylacetamide