(1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester
CAS No.:912807-23-9
Molecular Formula:C₁₆H₂₃FO₃Si
Molecular Weight:310.441
Hs Code.:

Synonyms:(1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

Chemical Property:

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Technology Process of (1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

There total 2 articles about (1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 75-77-4
chloro-trimethyl-silane

: 190269-75-1
methyl (1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate

: 912807-23-9
(1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/jo061268x

Reference yield:

: 190269-78-4
(1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylic acid

: 912807-23-9
(1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / 1 h / Heating

2: 94 percent / Et₃N / CH₂Cl₂ / 0 °C

With hydrogenchloride; triethylamine; In dichloromethane;
DOI:10.1021/jo061268x

Reference yield:

: 912807-23-9
(1R,2R,3S)-2-(4-Fluoro-phenyl)-3-trimethylsilanyloxy-cyclopentanecarboxylic acid methyl ester

: 30071-93-3
3,5-bis(trifluoromethyl)phenyl methyl ketone

: 190271-63-7
(1R,2R,3S)-3[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluorophenyl)cyclopentane-1-carboxylic acid methyl ester

: (1R,2R,3S)-3[(S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluorophenyl)cyclopentane-1-carboxylic acid methyl ester

Guidance literature:: With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 - 20 ℃; for 18h;
DOI:10.1021/jo061268x