3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

Base Information

Chemical Name:3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide
CAS No.:1372590-12-9
Molecular Formula:C₂₇H₂₄N₆O₄S
Molecular Weight:528.591
Hs Code.:

Synonyms:3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

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Chemical Property of 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

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Technology Process of 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

There total 11 articles about 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372590-09-4
3-(2-(N-methylmethylsulfonamido)phenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxylic acid

: 45588-79-2
1-(pyrimidin-4-yl)methanamine

: 1372590-12-9
3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl acetamide; at 20 ℃;

Reference yield:

: 181765-85-5
methyl 2-iodo 4-chlorobenzoate

: 1372590-12-9
3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; copper / chlorobenzene / 135 °C

2.1: hydrogenchloride / water; methanol / 20 h / Reflux

3.1: cesium fluoride / DavePhos; palladium diacetate / 1,2-dimethoxyethane; methanol / 12 h / Reflux

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 25 °C

4.2: pH 2

5.1: triethylamine; HATU / N,N-dimethyl acetamide / 20 °C

With hydrogenchloride; water; copper; potassium carbonate; triethylamine; cesium fluoride; HATU; sodium hydroxide; palladium diacetate; DavePhos; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; N,N-dimethyl acetamide; water; chlorobenzene; 3.1: Suzuki Coupling;

Reference yield:

: 13421-13-1
4-chloro-2-iodobenzoic acid

: 1372590-12-9
3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / diethyl ether / 20 °C

2.1: potassium carbonate; copper / chlorobenzene / 135 °C

3.1: hydrogenchloride / water; methanol / 20 h / Reflux

4.1: cesium fluoride / DavePhos; palladium diacetate / 1,2-dimethoxyethane; methanol / 12 h / Reflux

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 25 °C

5.2: pH 2

6.1: triethylamine; HATU / N,N-dimethyl acetamide / 20 °C

With hydrogenchloride; methanol; water; copper; potassium carbonate; triethylamine; cesium fluoride; HATU; sodium hydroxide; palladium diacetate; DavePhos; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; N,N-dimethyl acetamide; water; chlorobenzene; 4.1: Suzuki Coupling;