THYMOPOIETIN II (34-36)

Base Information

• Chemical Name: THYMOPOIETIN II (34-36)
• CAS No.: 75958-14-4
• Molecular Formula: C₁₈H₂₅N₃O₇
• Molecular Weight: 395.412
• Mol file: 75958-14-4.mol

Synonyms:H-ASP-VAL-TYR-OH;ASP-VAL-TYR;THYMOPOIETIN II (34-36);TP II (34-36)

Chemical Property of THYMOPOIETIN II (34-36)

Chemical Property:

• PSA: 179.05000
• LogP: 0.92900
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THYMOPOIETIN II (34-36)

There total 10 articles about THYMOPOIETIN II (34-36) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Val-ONp (10512-93-3) → Aspartyl-valyl-tyrosine (75958-14-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NH₃ / 1.) chloroform, 15 min; 2.) dioxane, room temp., 48 h

2: hydrogen / Pd-C / methanol / 3.5 h / 0 °C

3: dioxane / 24 h

4: 4 N HBr / acetic acid; H₂O / 96 h

With ammonia; hydrogen bromide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; water; acetic acid;

Reference yield:

N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosine methyl ester (15149-72-1) → Aspartyl-valyl-tyrosine (75958-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / Pd-C / methanol / 3.5 h / 0 °C

2: dioxane / 24 h

3: 4 N HBr / acetic acid; H₂O / 96 h

With hydrogen bromide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; water; acetic acid;

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) → Aspartyl-valyl-tyrosine (75958-14-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NH₃ / 1.) chloroform, 15 min; 2.) dioxane, room temp., 48 h

2: hydrogen / Pd-C / methanol / 3.5 h / 0 °C

3: dioxane / 24 h

4: 4 N HBr / acetic acid; H₂O / 96 h

With ammonia; hydrogen bromide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; water; acetic acid;

upstream raw materials:

N^α-t-butoxycarbonyl-β-benzyl-L-aspartyl-L-valyl-L-tyrosine benzyl ester

t-Boc-L-valine

H-Val-Tyr-OBzl

L-tyrosine benzyl ester p-toluenesulfonate

Downstream raw materials:

H-L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH*3HOAc

C₆₂H₇₃N₉O₁₇

Refernces

• 1、 Abiko,Onodera,Sekino. "The effect of thymopoietin II fragments and their analogs on E-rosette forming cells in the uremic state". . p. 2507 - 2511. Retrieved 2007/10/02.