N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

Base Information

Chemical Name:N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide
CAS No.:1272675-86-1
Molecular Formula:C₂₈H₂₉Cl₃N₂O₅
Molecular Weight:579.908
Hs Code.:

Synonyms:N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

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Chemical Property of N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

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Technology Process of N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

There total 3 articles about N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1103501-79-6
C₂₉H₃₄N₂O₃

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1272675-86-1
N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

Guidance literature:: With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-77-4
C₂₂H₂₈N₄O₂

: 1272675-86-1
N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen / methanol / 12 h / 20 °C

2: pyridine / 3 h / 20 °C / Inert atmosphere

3: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-78-5
(17-cyclopropylmethyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methanamine

: 1272675-86-1
N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h / 20 °C / Inert atmosphere

2: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 20 °C / Inert atmosphere

With pyridine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane;
DOI:10.1016/j.bmc.2010.12.035