(S)-pent-1-yne-1,3-diyldibenzene

Base Information

• Chemical Name: (S)-pent-1-yne-1,3-diyldibenzene
• CAS No.: 1062518-26-6
• Molecular Formula: C₁₇H₁₆
• Molecular Weight: 220.314
• Mol file: 1062518-26-6.mol

Synonyms:(S)-pent-1-yne-1,3-diyldibenzene

Chemical Property of (S)-pent-1-yne-1,3-diyldibenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-pent-1-yne-1,3-diyldibenzene

There total 5 articles about (S)-pent-1-yne-1,3-diyldibenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-((R)-1-phenylpent-1-yn-3-yl)-2-(S)-(p-tolylsulfinyl)benzene (1402231-87-1) → (S)-pent-1-yne-1,3-diyldibenzene (1062518-26-6)

Guidance literature:

1-((R)-1-phenylpent-1-yn-3-yl)-2-(S)-(p-tolylsulfinyl)benzene; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

In tetrahydrofuran; hexane; water; at -78 ℃; Inert atmosphere;

DOI:10.1002/chem.201201607

Reference yield:

ethylphenylzinc (313374-39-9) + (+/-)-(3-bromopent-1-ynyl)benzene (27975-81-1) → (S)-pent-1-yne-1,3-diyldibenzene (1062518-26-6) + (R)-pent-1-yne-1,3-diyldibenzene (1062518-02-8)

Guidance literature:

ethylphenylzinc; With [nickel(II)dichloride(dimethoxyethane)]; [3aS-[2(3'aRS,8'aSR),3aα,8aα]]-2,2'-(2,6-pyridinediyl)bis-[3a,8a-dihydro-8H-indeno[1,2-d]oxazole]; In diethylene glycol dimethyl ether; at 20 ℃; for 0.166667h; Inert atmosphere;

(+/-)-(3-bromopent-1-ynyl)benzene; In diethylene glycol dimethyl ether; at -20 ℃; for 14h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja805165y

Reference yield:

copper(I) phenylacetylenide (13146-23-1) + 1-bromopropylbenzene (2114-36-5,101308-38-7) → (S)-pent-1-yne-1,3-diyldibenzene (1062518-26-6) + (R)-pent-1-yne-1,3-diyldibenzene (1062518-02-8)

Guidance literature:

With copper(I) thiophene-2-carboxylate; C₃₉H₃₈N₃O₂P; caesium carbonate; In diethyl ether; at 20 ℃; Overall yield = 82 percent; enantioselective reaction; Inert atmosphere;

DOI:10.1038/s41557-019-0346-2

upstream raw materials:

ethylphenylzinc

(+/-)-(3-bromopent-1-ynyl)benzene

1-((R)-1-phenylpent-1-yn-3-yl)-2-(S)-(p-tolylsulfinyl)benzene

1-methyl-4-((phenylethynyl)sulfonyl)benzene