(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester

Base Information

• Chemical Name: (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester
• CAS No.: 503130-85-6
• Molecular Formula: C₃₀H₃₁IN₂O₆
• Molecular Weight: 642.49
• Mol file: 503130-85-6.mol

Synonyms:(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester

Chemical Property of (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester

There total 3 articles about (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-amino-3-iodobenzoic acid methyl ester (19718-49-1) + (S)-Fmoc-Ser(t-Bu)-Cl (136583-10-3) → (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester (503130-85-6)

Guidance literature:

With silver cyanide; In dichloromethane; for 48h;

DOI:10.1021/jo026693e

Reference yield:

Fmoc-Ser(tBu)-OH (71989-33-8) → (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester (503130-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂; dimethylformamide / 3 h

2: 81 percent / AgCN / CH₂Cl₂ / 48 h

With thionyl chloride; silver cyanide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo026693e

Reference yield:

4-methoxycarbonyl aniline (619-45-4) → (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester (503130-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / ICl; AcOH / 1 h / 20 °C

2: 81 percent / AgCN / CH₂Cl₂ / 48 h

With silver cyanide; Iodine monochloride; acetic acid; In dichloromethane;

DOI:10.1021/jo026693e

upstream raw materials:

4-amino-3-iodobenzoic acid methyl ester

(S)-Fmoc-Ser(t-Bu)-Cl

Fmoc-Ser(tBu)-OH

4-methoxycarbonyl aniline

Downstream raw materials:

(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester