(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

Base Information

Chemical Name:(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester
CAS No.:503130-86-7
Molecular Formula:C₃₂H₃₃IN₂O₆
Molecular Weight:668.528
Hs Code.:

Synonyms:(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

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Chemical Property of (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

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Technology Process of (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

There total 5 articles about (S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 107-18-6
allyl alcohol

: 503130-85-6
(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid methyl ester

: 503130-86-7
(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

Guidance literature:: With titanium(IV) isopropylate; at 120 ℃; for 1h;
DOI:10.1021/jo026693e

Reference yield:

: 19718-49-1
4-amino-3-iodobenzoic acid methyl ester

: 503130-86-7
(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / AgCN / CH₂Cl₂ / 48 h

2: 98 percent / Ti(O-i-Pr)4 / 1 h / 120 °C

With titanium(IV) isopropylate; silver cyanide; In dichloromethane;
DOI:10.1021/jo026693e

Reference yield:

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 503130-86-7
(S)-4-[3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-iodobenzoic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂; dimethylformamide / 3 h

2: 81 percent / AgCN / CH₂Cl₂ / 48 h

3: 98 percent / Ti(O-i-Pr)4 / 1 h / 120 °C

With titanium(IV) isopropylate; thionyl chloride; silver cyanide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo026693e