Technology Process of 2-(4-iodophenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile
There total 5 articles about 2-(4-iodophenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[2-(2,4,6-cycloheptatriene-1-yl)-1-(4-iodophenyl)ethylidene]propanedinitrile;
With
trityl tetrafluoroborate;
In
1,2-dichloro-ethane;
at 80 ℃;
for 1h;
With
triethylamine;
In
1,2-dichloro-ethane; toluene;
at 0 - 20 ℃;
for 1h;
In
1,2-dichloro-ethane; toluene;
at 80 ℃;
for 1h;
in dark;
DOI:10.1002/1522-2675(20010418)84:4<743::AID-HLCA743>3.0.CO;2-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 50 percent / methanol; acetic acid / 6 h / 20 °C
2.1: 69 percent / NH4OAc / toluene; acetic acid / 96 h / Heating
3.1: 100 percent / Et3N / CH2Cl2 / 1 h / -78 °C
4.1: Ph3CBF4 / 1,2-dichloro-ethane / 1 h / 80 °C
4.2: Et3N / 1,2-dichloro-ethane; toluene / 1 h / 0 - 20 °C
4.3: 70 percent / 1,2-dichloro-ethane; toluene / 1 h / 80 °C / in dark
With
ammonium acetate; trityl tetrafluoroborate; triethylamine;
In
methanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;
DOI:10.1002/1522-2675(20010418)84:4<743::AID-HLCA743>3.0.CO;2-1
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 69 percent / NH4OAc / toluene; acetic acid / 96 h / Heating
2.1: 100 percent / Et3N / CH2Cl2 / 1 h / -78 °C
3.1: Ph3CBF4 / 1,2-dichloro-ethane / 1 h / 80 °C
3.2: Et3N / 1,2-dichloro-ethane; toluene / 1 h / 0 - 20 °C
3.3: 70 percent / 1,2-dichloro-ethane; toluene / 1 h / 80 °C / in dark
With
ammonium acetate; trityl tetrafluoroborate; triethylamine;
In
dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;
DOI:10.1002/1522-2675(20010418)84:4<743::AID-HLCA743>3.0.CO;2-1