Technology Process of N-(S)-α-methylbenzyl-O-3,5-di-tert-butylbenzoyl hydroxylamine
There total 4 articles about N-(S)-α-methylbenzyl-O-3,5-di-tert-butylbenzoyl hydroxylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,5-di-tert-butylbenzoic acid;
With
1,1'-carbonyldiimidazole;
In
dichloromethane;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
N-((1S)-1-phenylethyl)hydroxylamine;
In
dichloromethane;
for 1h;
Inert atmosphere;
DOI:10.1039/c2ob25293g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dichloromethane / 1 h / 20 °C / pH 10.5 / Inert atmosphere
1.2: Inert atmosphere
2.1: ammonium hydroxide / methanol / 20 °C / Inert atmosphere
3.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
With
ammonium hydroxide; 1,1'-carbonyldiimidazole;
In
methanol; dichloromethane;
DOI:10.1039/c2ob25293g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane; water / 18 h / 20 °C / pH 10.5 / aq. buffer; Inert atmosphere
1.2: Inert atmosphere
2.1: dichloromethane / 1 h / 20 °C / pH 10.5 / Inert atmosphere
2.2: Inert atmosphere
3.1: ammonium hydroxide / methanol / 20 °C / Inert atmosphere
4.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
4.2: 1 h / Inert atmosphere
With
ammonium hydroxide; 1,1'-carbonyldiimidazole;
In
methanol; dichloromethane; water;
DOI:10.1039/c2ob25293g
