2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

Base Information

Chemical Name:2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide
CAS No.:932042-79-0
Molecular Formula:C₂₃H₂₆N₂O₂
Molecular Weight:362.472
Hs Code.:

Synonyms:2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

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Chemical Property of 2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

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Technology Process of 2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

There total 15 articles about 2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: C₂₃H₂₅NO₃

: 74-89-5
methylamine

: 932042-79-0
2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

Guidance literature:: In ethanol; at 60 ℃; for 24h;
DOI:10.1021/acs.orglett.8b00045

Reference yield:

: C₂₉H₃₀N₂O₃

: 932042-79-0
2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 12 h / 25 °C

2: methanol / 0.67 h / 0 °C / Inert atmosphere

3: ethanol / 24 h / 60 °C

With dmap; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/acs.orglett.8b00045

Reference yield:

: 1464140-80-4
C₂₄H₁₉NO₃

: 932042-79-0
2-[1-benzyl-3-(3-methylbuty-2-en-1-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: zinc; cerium(III) chloride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2: hydroxylamine hydrochloride; sodium acetate / methanol / 12 h / Reflux

3: 2,4,6-trichlorobenzenesulfonyl chloride; triethylamine / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

4: triethylamine; dmap / dichloromethane / 12 h / 25 °C

5: methanol / 0.67 h / 0 °C / Inert atmosphere

6: ethanol / 24 h / 60 °C

With dmap; cerium(III) chloride; 2,4,6-trichlorobenzenesulfonyl chloride; hydroxylamine hydrochloride; sodium acetate; triethylamine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3: |Beckmann Rearrangement;
DOI:10.1021/acs.orglett.8b00045