4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1005402-97-0
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428
• Mol file: 1005402-97-0.mol

Synonyms:4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + 4-hydroxypropiophenone (70-70-2) → 4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester (1005402-97-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.01.026

Reference yield:

4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester (1005402-97-0) + ethyl bromoacetate (105-36-2) → 4-[4-(3-ethoxycarbonyl-2-methyl-propionyl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester (1005402-98-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.bmcl.2012.01.026

Reference yield:

4-(4-propionylphenoxy)-piperidine-1-carboxylic acid tert-butyl ester (1005402-97-0) → C20H25N3O2 (1005401-02-4)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium diisopropyl amide / tetrahydrofuran / 0 °C

2: hydrazine hydrate / isopropyl alcohol / 110 °C

3: trifluoroacetic acid / dichloromethane / 25 °C

4: sodium cyanoborohydride / methanol; acetic acid; N,N-dimethyl-formamide / 60 °C

5: caesium carbonate / dimethyl sulfoxide / 100 °C

With sodium cyanoborohydride; caesium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2012.01.026

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

4-hydroxypropiophenone

Downstream raw materials:

C₂₀H₂₅N₃O₂

4-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester

5-methyl-6-[4-(piperidin-4-yloxy)-phenyl]-4,5-dihydro-2H-pyridazin-3-one

4-[4-(3-ethoxycarbonyl-2-methyl-propionyl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester