(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Base Information

Chemical Name:(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
CAS No.:1262396-58-6
Molecular Formula:C₂₁H₂₈N₂O₃
Molecular Weight:356.465
Hs Code.:

Synonyms:(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

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Chemical Property of (1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

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Technology Process of (1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

There total 2 articles about (1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-31-6
maleic anhydride

: 1262396-56-4
1-cyclohexyl-N-[(1S)-1-(furan-2-yl)ethyl]piperidin-4-amine

: 1262396-58-6
(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Guidance literature:: maleic anhydride; 1-cyclohexyl-N-[(1S)-1-(furan-2-yl)ethyl]piperidin-4-amine; In toluene; for 16h; Reflux;

With hydrogenchloride; In water; at 100 ℃; for 2h;

Reference yield:

: 16771-84-9
1-cyclohexyl-4-piperidinone

: 1262396-58-6
(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; titanium tetrachloride / dichloromethane / 16 h / Inert atmosphere

1.2: 4 h

2.1: toluene / 16 h / Reflux

2.2: 2 h / 100 °C

With titanium tetrachloride; triethylamine; In dichloromethane; toluene; 2.1: Diels-Alder Reaction;

Reference yield: 40.0%

: 1262396-58-6
(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

: 1262395-13-0
NMS-P₅₁₅

Guidance literature:: With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; for 16h; Inert atmosphere;