1262395-13-0Relevant articles and documents
Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515
Papeo, Gianluca,Orsini, Paolo,Avanzi, Nilla R.,Borghi, Daniela,Casale, Elena,Ciomei, Marina,Cirla, Alessandra,Desperati, Viviana,Donati, Daniele,Felder, Eduard R.,Galvani, Arturo,Guanci, Marco,Isacchi, Antonella,Posteri, Helena,Rainoldi, Sonia,Riccardi-Sirtori, Federico,Scolaro, Alessandra,Montagnoli, Alessia
, p. 534 - 538 (2019/03/26)
Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD+ to modify substrate proteins via the attachment of poly(ADP-ribose) chains. PARP-1 is a well established targe