Technology Process of 1-(2-cyclopropyl-5-(methoxymethyl)phenyl)ethanamine
There total 5 articles about 1-(2-cyclopropyl-5-(methoxymethyl)phenyl)ethanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl magnesium iodide; 2-cyclopropyl-5-(methoxymethyl)benzonitrile;
In
tetrahydrofuran; diethyl ether;
at 0 - 60 ℃;
for 2h;
Inert atmosphere;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran; diethyl ether;
at 0 - 20 ℃;
for 17h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium diacetate; ruphos; potassium phosphate / toluene / 16 h / 110 °C / Sealed tube; Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 60 °C / Inert atmosphere
4.2: 17 h / 0 - 20 °C / Reflux
With
sodium tetrahydroborate; potassium phosphate; palladium diacetate; sodium hydride; ruphos;
In
tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium bromide / 1-methyl-pyrrolidin-2-one / 84 h / 150 °C / Inert atmosphere
2.1: palladium diacetate; ruphos; potassium phosphate / toluene / 16 h / 110 °C / Sealed tube; Inert atmosphere
3.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 60 °C / Inert atmosphere
5.2: 17 h / 0 - 20 °C / Reflux
With
sodium tetrahydroborate; potassium phosphate; palladium diacetate; sodium hydride; lithium bromide; ruphos;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; N,N-dimethyl-formamide; toluene; mineral oil;
