Technology Process of 2-cyclopropyl-5-(methoxymethyl)benzonitrile
There total 4 articles about 2-cyclopropyl-5-(methoxymethyl)benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-cyclopropyl-5-(hydroxymethyl)benzonitrile;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.75h;
Inert atmosphere;
methyl iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate; ruphos; potassium phosphate / toluene / 16 h / 110 °C / Sealed tube; Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C
With
sodium tetrahydroborate; potassium phosphate; palladium diacetate; sodium hydride; ruphos;
In
methanol; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium bromide / 1-methyl-pyrrolidin-2-one / 84 h / 150 °C / Inert atmosphere
2.1: palladium diacetate; ruphos; potassium phosphate / toluene / 16 h / 110 °C / Sealed tube; Inert atmosphere
3.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere
4.2: 16 h / 20 °C
With
sodium tetrahydroborate; potassium phosphate; palladium diacetate; sodium hydride; lithium bromide; ruphos;
In
1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; toluene; mineral oil;
