Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Base Information

Chemical Name:Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
CAS No.:157071-66-4
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:

Synonyms:Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

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Chemical Property of Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

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Technology Process of Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

There total 5 articles about Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 107-06-2,52399-93-6
1,2-dichloro-ethane

: 157071-60-8
Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate

: 157071-66-4
Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; for 44h; Heating;
DOI:10.1021/jo00097a025

Reference yield:

: 157071-48-2
(1H-pyrrol-2-yl)acetic acid isopropyl ester

: 157071-66-4
Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h

2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH₂Cl₂, r.t., 15 h

3: 68 percent / K₂CO₃, n-Bu₄NBr / 44 h / Heating

With oxalyl dichloride; tetrabutylammomium bromide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00097a025

Reference yield:

: 157071-65-3
Isopropyl (5-benzoylpyrrol-2-yl)acetate

: 157071-66-4
Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h

2: 68 percent / K₂CO₃, n-Bu₄NBr / 44 h / Heating

With tetrabutylammomium bromide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00097a025