2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

Base Information

Chemical Name:2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile
CAS No.:1360056-35-4
Molecular Formula:C₂₀H₁₄BrFN₂O₂
Molecular Weight:413.246
Hs Code.:

Synonyms:2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

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Chemical Property of 2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

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Technology Process of 2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

There total 11 articles about 2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360056-34-3
2-(8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

: 67713-23-9
2,6-dibromobenzaldehyde

: 1360056-35-4
2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

Guidance literature:: With copper(l) iodide; sodium hydrogencarbonate; In dimethyl sulfoxide; ethyl acetate; at 110 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 28314-80-9
2,4,6-trifluorobenzoic acid

: 1360056-35-4
2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: dichloromethane / 0 - 20 °C

2.1: thionyl chloride / dichloromethane / 20 °C / Cooling with ice bath

3.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

4.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 - 15 °C / Inert atmosphere

5.1: acetonitrile / 63 °C

6.1: sodium hydroxide; water / methanol / 1 h / 80 °C

6.2: pH 1

7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

7.2: 4 h

8.1: tetrahydrofuran / 3 h / 63 °C

9.1: potassium tert-butylate / tetrahydrofuran / 2.25 h / 55 - 62 °C

10.1: sodium hydrogencarbonate; copper(l) iodide / ethyl acetate; dimethyl sulfoxide / 3.5 h / 110 °C / Inert atmosphere

With copper(l) iodide; thionyl chloride; potassium tert-butylate; water; potassium hexamethylsilazane; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 1360056-29-6
2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

: 1360056-35-4
2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 63 °C

2.1: sodium hydroxide; water / methanol / 1 h / 80 °C

2.2: pH 1

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

3.2: 4 h

4.1: tetrahydrofuran / 3 h / 63 °C

5.1: potassium tert-butylate / tetrahydrofuran / 2.25 h / 55 - 62 °C

6.1: sodium hydrogencarbonate; copper(l) iodide / ethyl acetate; dimethyl sulfoxide / 3.5 h / 110 °C / Inert atmosphere

With copper(l) iodide; potassium tert-butylate; water; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate; acetonitrile;