ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate
• CAS No.: 1246655-00-4
• Molecular Formula: C₁₆H₂₉IO₄Si
• Molecular Weight: 440.394
• Mol file: 1246655-00-4.mol

Synonyms:ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate

Chemical Property of ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate

There total 6 articles about ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H28O4Si → ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate (1246655-00-4)

Guidance literature:

With diiodomethane; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 14h;

DOI:10.1039/c0ob00632g

Reference yield:

diiodomethane (75-11-6) + C15H28O4Si → ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate (1246655-00-4)

Guidance literature:

C₁₅H₂₈O₄Si; With sodium hydride; In dimethyl sulfoxide; mineral oil; for 0.25h;

diiodomethane; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 14h;

DOI:10.1039/c0ob00632g

Reference yield:

4-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol (126931-29-1) → ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate (1246655-00-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C

2: sodium hydride / 2 h / 140 °C

3: diiodomethane; sodium hydride / dimethyl sulfoxide / 14 h / 20 °C

With diiodomethane; sodium hydride; pyridinium chlorochromate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/c0ob00632g

upstream raw materials:

diiodomethane

1,4-Cyclohexanediol

4-(tert-butyldimethylsilyloxy)cyclohexanone

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₅₇H₉₆O₁₅Si₃