(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Base Information

Chemical Name:(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate
CAS No.:1261286-61-6
Molecular Formula:CH₄O₃S*C₂₂H₂₆N₂O₂S
Molecular Weight:478.634
Hs Code.:

Synonyms:(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

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Technology Process of (R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

There total 5 articles about (R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196663-24-7
(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

: 1261286-61-6
(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Guidance literature:: With hydrogen; 5% Pd(II)/C(eggshell); In water; acetone; at 25 - 35 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 180637-88-1
(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

: 75-75-2,98527-29-8
methanesulfonic acid

: 1261286-61-6
(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Guidance literature:: (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole; With methanol; potassium carbonate; at 25 - 35 ℃;

methanesulfonic acid; With hydrogen; 5% Pd(II)/C(eggshell); In water; acetone; at 25 - 35 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 208464-41-9,312949-16-9
5-bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole

: 1261286-61-6
(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 25 - 83 °C

2.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C

2.2: 25 - 83 °C

3.1: potassium carbonate; methanol / 25 - 35 °C

3.2: 25 - 30 °C

4.1: hydrogen / 5% Pd(II)/C(eggshell) / water; acetone / 25 - 35 °C / Inert atmosphere

With methanol; hydrogen; potassium carbonate; triethylamine; 5% Pd(II)/C(eggshell); palladium diacetate; tris-(o-tolyl)phosphine; In water; acetone; acetonitrile;