endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide

Base Information

• Chemical Name: endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide
• CAS No.: 145449-99-6
• Molecular Formula: C₂₄H₃₄NO₂*I
• Molecular Weight: 495.444
• Mol file: 145449-99-6.mol

Synonyms:endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide

Chemical Property of endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide

There total 5 articles about endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate (145449-95-2) + methyl iodide (74-88-4) → endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide (145449-99-6)

Guidance literature:

In acetonitrile; at 50 ℃; for 3h;

DOI:10.1016/0223-5234(92)90179-5

Reference yield: 25.0%

2-iodo-propane (75-30-9) + 8-aza-8-methylbicyclo [3.2.1]oct-3-yl 2-phenylcyclohex-2-enecarboxylate (24259-15-2) → endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide (145449-99-6) + endo-syn-8-(1-methylethyl)-8-methyl-3-<<(2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide (145449-77-0)

Guidance literature:

In acetonitrile; for 168h; Ambient temperature;

DOI:10.1016/0223-5234(92)90179-5

Reference yield:

2-phenyl-2-cyclohexene-1-carbonyl chloride (145450-39-1) → endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide (145449-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / triethylamine / 1,2-dichloro-ethane / 9 h / Heating

2: 89 percent / acetonitrile / 3 h / 50 °C

With triethylamine; In 1,2-dichloro-ethane; acetonitrile;

DOI:10.1016/0223-5234(92)90179-5

upstream raw materials:

2-iodo-propane

8-aza-8-methylbicyclo [3.2.1]oct-3-yl 2-phenylcyclohex-2-enecarboxylate

endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

methyl iodide