4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

Base Information

Chemical Name:4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile
CAS No.:1614246-79-5
Molecular Formula:C₂₃H₂₀FNO₄S
Molecular Weight:425.481
Hs Code.:

Synonyms:4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

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Chemical Property of 4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

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Technology Process of 4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

There total 9 articles about 4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 956034-22-3
2-(2-fluoro-5-((4-methoxybenzyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1614246-78-4
2-bromo-5-(ethylsulfonyl)benzonitrile

: 1614246-79-5
4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 110 ℃; for 12h; Inert atmosphere;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1614246-79-5
4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / 16.66 h / Reflux

2: hydrazine hydrate / tetrahydrofuran / 0 - 20 °C

3: sodium acetate / 20 h / Reflux

4: 1,1'-carbonyldiimidazole; ammonia / tetrahydrofuran / 0.75 h / 22 - 41 °C / Inert atmosphere

5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 16 h / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium acetate; sodium carbonate; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 3285-31-2
2-bromo-5-(chlorosulfonyl)benzoic acid

: 1614246-79-5
4-(ethylsulfonyl)-2'-fluoro-5'-((4-methoxybenzyl)oxy)[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / tetrahydrofuran / 0 - 20 °C

2: sodium acetate / 20 h / Reflux

3: 1,1'-carbonyldiimidazole; ammonia / tetrahydrofuran / 0.75 h / 22 - 41 °C / Inert atmosphere

4: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 16 h / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium acetate; sodium carbonate; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; water;