2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

Base Information

Chemical Name:2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile
CAS No.:129975-51-5
Molecular Formula:C₂₅H₃₃N₃O₄
Molecular Weight:439.555
Hs Code.:

Synonyms:2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

Suppliers and Price of 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

There total 6 articles about 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 27487-83-8
2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile

: 40172-95-0
N-(furan-2-carbonyl)piperazine

: 129975-51-5
2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

Guidance literature:: With potassium carbonate; potassium iodide; In butanone; for 40h; Heating;
DOI:10.1016/0223-5234(90)90119-N

Reference yield:

: 20850-49-1
2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile

: 129975-51-5
2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaNH₂ / toluene / 5 h / Heating

2: oxalic acid / acetone; H₂O / 3 h / 40 °C

3: 90percent formic acid / toluene / 1 h / Heating

With formic acid; oxalic acid; sodium amide; In water; acetone; toluene;
DOI:10.1135/cccc19921967

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 129975-51-5
2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 5 h, 2.) RT, overnight

2: 94 percent / potassium, Tebac / tetrahydrofuran / 36 h / Heating

3: 60 percent / K₂CO₃, KI / butan-2-one / 40 h / Heating

With N-benzyl-N,N,N-triethylammonium chloride; potassium; sodium hydride; potassium carbonate; potassium iodide; In tetrahydrofuran; butanone;
DOI:10.1016/0223-5234(90)90119-N