C₂₃H₂₇N₅O₅

Base Information

• Chemical Name: C₂₃H₂₇N₅O₅
• CAS No.: 1428305-97-8
• Molecular Formula: C₂₃H₂₇N₅O₅
• Molecular Weight: 453.498
• Mol file: 1428305-97-8.mol

Synonyms:C₂₃H₂₇N₅O₅

Chemical Property of C₂₃H₂₇N₅O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₇N₅O₅

There total 6 articles about C₂₃H₂₇N₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid (864076-03-9) + methyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (162085-97-4) → C23H27N5O5 (1428305-97-8)

Guidance literature:

4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl 4-amino-1-methyl-1H-imidazole-2-carboxylate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/jm301882a

Reference yield:

4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester (1196-90-3) → C23H27N5O5 (1428305-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 6 h / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki Coupling;

DOI:10.1021/jm301882a

Reference yield:

1-methyl-2-trichloroacetyl-1H-pyrrole (21898-65-7) → C23H27N5O5 (1428305-97-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 6 h / -10 - 20 °C

2.1: sodium methylate / 0.5 h / Reflux

2.2: pH 2

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

4.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 6 h / 20 °C

With dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 3.1: |Suzuki Coupling;

DOI:10.1021/jm301882a

upstream raw materials:

1-methyl-2-trichloroacetyl-1H-pyrrole

1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one

N-Methylpyrrole

4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester

Downstream raw materials:

methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

C₂₂H₂₅N₅O₅

C₂₉H₃₃N₇O₆

methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate