Technology Process of 3-isopropyl-2,2-dimethylcyclohexanone
There total 2 articles about 3-isopropyl-2,2-dimethylcyclohexanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-Isopropyl-2-methyl-1-trimethylsiloxycyclohex-1-ene;
With
methyllithium;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
methyl iodide;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1039/c0cc04725b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
1.2: 1 h / -40 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: methyllithium / tetrahydrofuran / 0.25 h / 0 °C
2.2: -78 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex; methyllithium;
In
tetrahydrofuran;
DOI:10.1039/c0cc04725b
- Guidance literature:
-
ethyl vinyl ether;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 - 0 ℃;
for 0.416667h;
Inert atmosphere;
3-isopropyl-2,2-dimethylcyclohexanone;
In
tetrahydrofuran; pentane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1039/c0cc04725b
