C₁₃H₁₃BrO₅

Base Information

• Chemical Name: C₁₃H₁₃BrO₅
• CAS No.: 1026189-07-0
• Molecular Formula: C₁₃H₁₃BrO₅
• Molecular Weight: 329.147
• Mol file: 1026189-07-0.mol

Synonyms:C₁₃H₁₃BrO₅

Chemical Property of C₁₃H₁₃BrO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₃BrO₅

There total 1 articles about C₁₃H₁₃BrO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-oxo-4-(4-bromophenyl)butanoic acid (6340-79-0) + chloroformic acid ethyl ester (541-41-3) → C13H13BrO5 (1026189-07-0)

Guidance literature:

With TEA; In tetrahydrofuran; at -10 ℃; for 0.5h;

DOI:10.1021/jm00357a013

Reference yield:

C13H13BrO5 (1026189-07-0) → 1-<3-(4-bromobenzoyl)propionyl>-L-proline (75381-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N / 1.) CH₂Cl₂, -5 deg C, 15 min, 2.) CH₂Cl₂, THF, 20 deg C, 1 h

2: 60 percent / 1 N aq. NaOH / tetrahydrofuran / 48 h / Ambient temperature

With sodium hydroxide; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00357a013

Reference yield:

di-n-propylamine (142-84-7) + C13H13BrO5 (1026189-07-0) → 4-(4-Bromo-phenyl)-4-oxo-N,N-dipropyl-butyramide

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jm00072a010

upstream raw materials:

4-oxo-4-(4-bromophenyl)butanoic acid

chloroformic acid ethyl ester

Downstream raw materials:

1-<3-(4-bromoobenzoyl)propionyl>-L-proline methyl ester

1-[3-(4-Bromobenzoyl)propionyl]-L-proline tert-butyl ester

1-<3-(4-bromobenzoyl)propionyl>-L-proline

1-<3-(4-bromobenzoyl)propionyl>-L-proline

Refernces

• 1、 McEvoy, Francis J.,Lai, Fong M.,Albright, J. Donald. "Antihypertensive Agents: Angiotensin Converting Enzyme Inhibitors. 1--L-prolines". . p. 381 - 392. Retrieved 2007/10/02.