N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

Base Information

Chemical Name:N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester
CAS No.:618068-90-9
Molecular Formula:C₃₀H₃₁NO₆
Molecular Weight:501.579
Hs Code.:

Synonyms:N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

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Chemical Property of N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

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Technology Process of N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

There total 3 articles about N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 618068-80-7
1-[2-(2-methyl-[1,3]dioxolan-2-yl)phenyl]propan-2-ol

: 618068-90-9
N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/ol035782q

Reference yield:

: 50777-64-5
2-(2-bromophenyl)-2-methyl-1,3-dioxolane

: 618068-90-9
N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Li / diethyl ether / 2 h

1.2: 64 percent / diethyl ether / 2 h

2.1: 28 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂

With dmap; lithium; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/ol035782q

Reference yield:

: 2142-69-0
2-bromophenyl methyl ketone

: 618068-90-9
N-Fmoc-glycine 1-methyl-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: p-TsOH

2.1: Li / diethyl ether / 2 h

2.2: 64 percent / diethyl ether / 2 h

3.1: 28 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂

With dmap; lithium; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/ol035782q