1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

Base Information

Chemical Name:1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride
CAS No.:1370337-76-0
Molecular Formula:C₁₀H₉F₄NO*ClH
Molecular Weight:271.642
Hs Code.:

Synonyms:1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

Suppliers and Price of 1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of 1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

There total 2 articles about 1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370337-75-9
C₁₅H₁₇F₄NO₃

: 1370337-76-0
1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 10 ℃; Inert atmosphere;
DOI:10.1021/op200351g

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1370337-76-0
1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 5.17 h / 20 - 45 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 0 - 10 °C / Inert atmosphere

With hydrogenchloride; isopropylmagnesium chloride; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/op200351g

Reference yield: 65.0%

: 1370337-76-0
1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1370337-77-1
tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate; at 0 - 5 ℃; for 0.416667h;
DOI:10.1021/op200351g