tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate
CAS No.:1370337-77-1
Molecular Formula:C₂₁H₂₆F₄N₂O₄
Molecular Weight:446.442
Hs Code.:

Synonyms:tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1370337-76-0
1-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(methylamino)ethanone hydrochloride

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1370337-77-1
tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate; at 0 - 5 ℃; for 0.416667h;
DOI:10.1021/op200351g

Reference yield:

: 1370337-75-9
C₁₅H₁₇F₄NO₃

: 1370337-77-1
tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 0 - 10 °C / Inert atmosphere

2: 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 0.42 h / 0 - 5 °C

With 4-methyl-morpholine; hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/op200351g

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1370337-77-1
tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 5.17 h / 20 - 45 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 0 - 10 °C / Inert atmosphere

3: 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 0.42 h / 0 - 5 °C

With 4-methyl-morpholine; hydrogenchloride; isopropylmagnesium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/op200351g