Technology Process of ((2S,3S)-3-(4-(benzyloxy)butyl)oxiran-2-yl)methanol
There total 6 articles about ((2S,3S)-3-(4-(benzyloxy)butyl)oxiran-2-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-7-(benzyloxy)-2-hepten-1-ol;
With
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate;
In
dichloromethane;
at -20 ℃;
for 0.5h;
Molecular sieve;
With
tert.-butylhydroperoxide;
In
dichloromethane; toluene;
at -20 ℃;
for 8h;
Molecular sieve;
DOI:10.1055/s-0031-1290156
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C
1.2: 10.17 h / 0 - 20 °C
2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1 h / -78 - 20 °C / Inert atmosphere
3.1: benzene / 1 h / 80 °C
4.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
5.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
5.2: 8 h / -20 °C / Molecular sieve
With
titanium(IV) isopropylate; aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; diethyl (2R,3R)-tartrate; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; mineral oil; benzene;
2.1: Swern oxidation / 3.1: Wittig reaction / 5.1: Sharpless epoxidation;
DOI:10.1055/s-0031-1290156
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C
1.2: 10.17 h / 0 - 20 °C
2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1 h / -78 - 20 °C / Inert atmosphere
3.1: benzene / 1 h / 80 °C
4.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
5.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
5.2: 8 h / -20 °C / Molecular sieve
With
titanium(IV) isopropylate; aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; diethyl (2R,3R)-tartrate; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; mineral oil; benzene;
2.1: Swern oxidation / 3.1: Wittig reaction / 5.1: Sharpless epoxidation;
DOI:10.1055/s-0031-1290156
