N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

Base Information

Chemical Name:N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine
CAS No.:1146972-28-2
Molecular Formula:C₂₁H₂₇N₃O₄S
Molecular Weight:417.529
Hs Code.:

Synonyms:N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

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Chemical Property of N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

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Technology Process of N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

There total 4 articles about N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146972-71-5
1-(3'-amino-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1146972-28-2
N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

Guidance literature:: 1-(3'-amino-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole; (2-chloroethyl)dimethylamine hydrochloride; In N,N-dimethyl-formamide; m-xylene; at 135 - 138 ℃; for 10h;

With sodium hydroxide; In water; N,N-dimethyl-formamide; m-xylene; pH=9 - 10;

Reference yield:

: 93-26-5
2-methoxyacetanilide

: 1146972-28-2
N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 26 h / 20 - 100 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

2.2: 24 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethanol; water / 2 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide; m-xylene / 10 h / 20 °C / Heating

With hydrogenchloride; chlorosulfonic acid; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; m-xylene;
DOI:10.3109/14756366.2014.889126

Reference yield:

: 1146972-70-4
1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole

: 1146972-28-2
N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide; m-xylene / 10 h / 20 °C / Heating

With hydrogenchloride; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; m-xylene;
DOI:10.3109/14756366.2014.889126