5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide

Base Information

• Chemical Name: 5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide
• CAS No.: 1417897-41-6
• Molecular Formula: C₁₃H₁₁N₅O₃
• Molecular Weight: 285.262
• Mol file: 1417897-41-6.mol

Synonyms:5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide

Chemical Property of 5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide

There total 1 articles about 5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 4-nitrophenyl azide (1516-60-5) + Propargylamine (2450-71-7) → 5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide (1417897-41-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; for 8h; chemoselective reaction; Reflux;

DOI:10.1002/ejoc.201201096

Reference yield: 84.0%

5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide (1417897-41-6) + Benzaldoxime (932-90-1) → C20H16N6O4 (1421780-51-9)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In methanol; at 40 ℃; for 1.5h; chemoselective reaction;

DOI:10.1039/c2ob26990b

Reference yield: 84.0%

5-methyl-1-(4-nitrophenyl)-N-(prop-2-ynyl)-1H-1,2,3-triazole-4-carboxamide (1417897-41-6) + benzyl azide (622-79-7) → N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]-5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carboxamide (1417897-28-9)

Guidance literature:

With copper(l) iodide; In dichloromethane; at 40 ℃; for 6h; chemoselective reaction;

DOI:10.1002/ejoc.201201096

upstream raw materials:

4-methyleneoxetan-2-one

4-nitrophenyl azide

Propargylamine

Downstream raw materials:

N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]-5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carboxamide

5-methyl-1-(4-nitrophenyl)-N-{[1-(2-oxo-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl]methyl}-1H-1,2,3-triazole-4-carboxamide

C₂₀H₁₆N₆O₄