8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

Base Information

Chemical Name:8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
CAS No.:1448466-65-6
Molecular Formula:C₁₁H₇FN₄OS
Molecular Weight:262.267
Hs Code.:

Synonyms:8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

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Chemical Property of 8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

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Technology Process of 8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

There total 3 articles about 8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: C₁₄H₁₄FN₃O₂S

: 1448466-65-6
8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

Guidance literature:: With sodium ethanolate; In ethanol; for 0.5h; Reflux;
DOI:10.1016/j.ejmech.2013.03.063

Reference yield:

: 5848-05-5
5-amino-4-(4-fluorophenyl)-1H-pyrazole

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 1448466-65-6
8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

Guidance literature:: 5-amino-4-(4-fluorophenyl)-1H-pyrazole; Ethoxycarbonyl isothiocyanate; In dichloromethane; at 0 - 20 ℃;

With potassium carbonate; In acetonitrile; at 90 ℃; for 2h;
DOI:10.1002/cmdc.201900193

Reference yield:

: 5848-04-4
3-amino-4-(4-fluorophenyl)-1H-pyrazole

: 1448466-65-6
8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium ethanolate / ethanol / 0.5 h / Reflux

With sodium ethanolate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.03.063