Technology Process of 6-Iodoisoquinoline
There total 7 articles about 6-Iodoisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; potassium iodide;
In
DMF (N,N-dimethyl-formamide);
at 130 ℃;
for 3h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 56 percent / pertrifluoroacetic acid / CH2Cl2 / 13 h / Ambient temperature
2: sodium borohydride / methanol / 3 h / Ambient temperature
3: 82 percent / p-Toluenesulfonic acid / benzene / 3 h / Heating
4: sulfurated sodium borohydride / tetrahydrofuran / 16 h / Ambient temperature
5: 1.) NaNO2, 20percent H2SO4, 2.) KI / 1.) H2O, 0 deg C, 12 min, 2.) H2O, flask in aluminum foil, 30 min stirring
With
sodium tetrahydroborate; sulfurated sodium borohydride; sulfuric acid; toluene-4-sulfonic acid; trifluoroacetic acid; potassium iodide; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo01314a019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / p-Toluenesulfonic acid / benzene / 3 h / Heating
2: sulfurated sodium borohydride / tetrahydrofuran / 16 h / Ambient temperature
3: 1.) NaNO2, 20percent H2SO4, 2.) KI / 1.) H2O, 0 deg C, 12 min, 2.) H2O, flask in aluminum foil, 30 min stirring
With
sulfurated sodium borohydride; sulfuric acid; toluene-4-sulfonic acid; potassium iodide; sodium nitrite;
In
tetrahydrofuran; benzene;
DOI:10.1021/jo01314a019
