3470-54-0

Basic information

• Product Name: 5-Aminoindan-1-one
• Synonyms: IFLAB-BB F0400-0036;5-AMINOINDAN-1-ONE;5-AMINO-1-INDANONE;5-Aminoindan-1-one, 95+%;5-amino-2,3-dihydroinden-1-one;5-aminoindanone;5-AMino-1-oxoindane;5-Amino-2,3-dihydro-1H-inden-1-one, 5-Amino-2,3-dihydro-1-oxo-1H-indene
• CAS NO: 3470-54-0
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: Amines;Fused Ring Systems
• Mol File: 3470-54-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 184 °C
• Boiling Point: 344.5 °C at 760 mmHg
• Flash Point: 162.1 °C
• Appearance: /Solid
• Density: 1.254 g/cm³
• Vapor Pressure: 6.57E-05mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.12±0.20(Predicted)
• CAS DataBase Reference: 5-Aminoindan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Aminoindan-1-one(3470-54-0)
• EPA Substance Registry System: 5-Aminoindan-1-one(3470-54-0)

Safety Data

• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-52/53-25-52
• Safety Statements: 36/37-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 3470-54-0(Hazardous Substances Data)

Usage

General Description

5-Aminoindan-1-one is a chemical compound with the molecular formula C9H9NO. It is a white solid that is used as a building block in the synthesis of various pharmaceuticals and other organic compounds. It is classified as an aminoindan, which is a class of organic compounds containing a bicyclic ring system with an amine group. The presence of the amino group in 5-Aminoindan-1-one makes it a versatile intermediate in the production of drugs and other biologically active molecules. 5-Aminoindan-1-one has applications in the pharmaceutical industry, as well as in academic research and chemical synthesis. Additionally, it is important to handle this chemical with care, as it can be hazardous if not properly managed and used in accordance with safety guidelines.

InChI:InChI=1/C9H9NO/c10-7-2-3-8-6(5-7)1-4-9(8)11/h2-3,5H,1,4,10H2

Upstream product

• 1116358-96-3 2-methyl-2-propanyl (1-oxo-2,3-dihydro-1H-inden-5-yl)carbamate 
• 34598-49-7 5-Bromo-1-indanone 
• 58161-34-5 3-Acetaminohydrozimtsaeuremethylester 
• 4080-83-5 3-acetylaminobenzene propanoic acid 
• 59856-06-3 5-acetamidoindane 
• 58161-35-6 5-acetamido-1-indanone 

Downstream Products

• 25724-79-2 5-cyano-1-indanone 
• 22246-24-8 5-nitro-2,3-dihydroinden-1-one 
• 511533-10-1 1-(2',4'-dichlorophenyl)-6-iodo-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acid 
• 511533-22-5 ethyl 1-(2',4'-dichlorophenyl)-6-iodo-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylate 
• 70538-57-7 6-nitroisoquinoline 
• 75476-84-5 6-Iodoisoquinoline 
• 875896-09-6 5-benzamidoindan-1-one 
• 268563-99-1 N-(2-benzylidene-1-oxoindan-5-yl)benzamide 
• 869725-57-5 5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol 

Relevant articles and documents

The role of internal twisting in the photophysics of stilbazolium dyes

The synthesis of selectively bridged stilbazolium dyes related to DASPMI is described. The comparison of steady-state and time-resolved fluorescence studies as a function of temperature allows one to develop a kinetic model on the basis of which the high photostability and absence of photoisomerization for these dyes can be understood. There are two possible photochemical deactivation channels: non-radiative decay through single-bond twisting which does not lead to a distinguishable photoisomer and through double bond twisting leading to trans-cis photoisomerization. The latter process is more than one order of magnitude slower than single-bond twisting for these compounds and is only observed in the compound where both single bonds are bridged. Lifetime maxima observed at low temperature indicate a further early structural relaxation not connected with bond twisting but with bond length changes.

Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists

A series of bicyclic analogues having indan and tetrahydronaphthalene templates in the A-region were designed as conformationally constrained analogues of our previously reported potent TRPV1 antagonists (1, 3). The activities for rat TRPV1 of the conformationally restricted analogues were moderately or markedly diminished, particularly in the case of the tetrahydronaphthalene analogues. The analysis indicated that steric constraints at the benzylic position in the bicyclic analogues may be an important factor for their unfavorable interaction with the receptor.