C₂₂H₃₀N₂O₃

Base Information

• Chemical Name: C₂₂H₃₀N₂O₃
• CAS No.: 1609644-26-9
• Molecular Formula: C₂₂H₃₀N₂O₃
• Molecular Weight: 370.492
• Mol file: 1609644-26-9.mol

Synonyms:C₂₂H₃₀N₂O₃

Chemical Property of C₂₂H₃₀N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₀N₂O₃

There total 2 articles about C₂₂H₃₀N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide (1609644-25-8) + pivalaldehyde (630-19-3) → C22H30N2O3 (1609644-26-9) + C22H30N2O3

Guidance literature:

2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide; With lithium chloride; In tetrahydrofuran; at 23 ℃; for 0.00833333h; Inert atmosphere;

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h; Inert atmosphere;

pivalaldehyde; In tetrahydrofuran; at -78 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201400928

Reference yield:

tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate (1609644-58-7) → C22H30N2O3 (1609644-26-9) + C22H30N2O3

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1.67 h / 0 - 23 °C / Inert atmosphere

2.1: lithium chloride / tetrahydrofuran / 0.01 h / 23 °C / Inert atmosphere

2.2: 0.5 h / -78 - 0 °C / Inert atmosphere

2.3: -78 °C / Inert atmosphere

With trifluoroacetic acid; lithium chloride; In tetrahydrofuran; dichloromethane; 2.3: |Aldol Addition;

DOI:10.1002/anie.201400928

Reference yield:

C22H30N2O3 (1609644-26-9) → C12H23NO5

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 23 °C

2: water; di-tert-butyl dicarbonate / 1,4-dioxane

With di-tert-butyl dicarbonate; water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol;

upstream raw materials:

2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide

pivalaldehyde

tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate