N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

Base Information

Chemical Name:N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide
CAS No.:1360630-34-7
Molecular Formula:C₂₅H₁₇F₃N₂O₂
Molecular Weight:434.417
Hs Code.:

N<sup>(2)</sup>-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

Synonyms:N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

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Chemical Property of N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

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Technology Process of N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

There total 5 articles about N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 149505-84-0
6-carbamoylnaphthalene-2-carboxylic acid

: 397-28-4
4-amino-3'-(trifluoromethyl)-1,1'-biphenyl

: 1360630-34-7
N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

Guidance literature:: 6-carbamoylnaphthalene-2-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.25h;

4-amino-3'-(trifluoromethyl)-1,1'-biphenyl; In N,N-dimethyl-formamide; for 48h;
DOI:10.1016/j.bmc.2011.12.040

Reference yield:

: 106-40-1
4-bromo-aniline

: 1360630-34-7
N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / Inert atmosphere; Reflux

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

2.2: 48 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.12.040

Reference yield:

: 69008-41-9
6-(Chlorocarbonyl)-2-naphthalenecarboxylic acid,methyl ester

: 1360630-34-7
N⁽²⁾-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water

2.2: pH 3

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

3.2: 48 h

With lithium hydroxide monohydrate; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.040