3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Base Information

Chemical Name:3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide
CAS No.:1240137-97-6
Molecular Formula:C₂₉H₂₅ClN₂O₆
Molecular Weight:532.98
Hs Code.:

Synonyms:3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Suppliers and Price of 3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

There total 12 articles about 3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1240137-96-5
3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(hydroxyacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

: 1240137-97-6
3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Guidance literature:: With copper diacetate; In methanol; at 50 - 60 ℃; for 2.5h;
DOI:10.1021/op100186c

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 1240137-97-6
3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethyl acetate / 1.5 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

2.2: 2 h / 60 °C

3.1: aluminum (III) chloride / 22 h / -5 °C

3.2: 35 - 50 °C

3.3: 18 h / 65 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

5.1: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

6.1: copper diacetate / methanol / 2.5 h / 50 - 60 °C

With aluminum (III) chloride; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; water; copper diacetate; potassium formate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethyl acetate; toluene; acetonitrile; 2.1: Mitsunobu reaction / 3.1: Friedel Crafts acylation;
DOI:10.1021/op100186c

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1240137-97-6
3-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[4-(oxoacetyl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 50 °C

1.2: 50 °C

2.1: water; potassium hydroxide / dimethyl sulfoxide / 80 - 85 °C

2.2: 50 - 60 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

6.1: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

7.1: copper diacetate / methanol / 2.5 h / 50 - 60 °C

With N-chloro-succinimide; oxalyl dichloride; tetrabutylammomium bromide; water; copper diacetate; potassium formate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/op100186c