(S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

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Chemical Name:(S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol
CAS No.:189571-87-7
Molecular Formula:C₂₁H₂₈Cl₂O₇
Molecular Weight:463.355
Hs Code.:

Synonyms:(S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

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Chemical Property of (S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

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Technology Process of (S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

There total 4 articles about (S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 75-09-2
dichloromethane

: 189571-83-3
2-Benzyloxy-1-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethanone

: 189571-87-7
(S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(97)00240-8

Reference yield:

: 100-39-0
benzyl bromide

: 189571-87-7
(S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / bis-tributylstannyl oxide, tetrabutylammonium bromide / benzene / 24 h / Heating

2: 95 percent / oxalyl chloride, DMSO, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / lithium diisopropylamide / tetrahydrofuran; hexane / -78 - 20 °C

With oxalyl dichloride; tetrabutylammomium bromide; dimethyl sulfoxide; triethylamine; bis(tri-n-butyltin)oxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; benzene;
DOI:10.1016/S0040-4020(97)00240-8

Reference yield:

: 1-((3aR,5aS,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethane-1,2-diol

: 189571-87-7
(S)-3-Benzyloxy-1,1-dichloro-2-((3aR,5S,5aR,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / bis-tributylstannyl oxide, tetrabutylammonium bromide / benzene / 24 h / Heating

2: 95 percent / oxalyl chloride, DMSO, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / lithium diisopropylamide / tetrahydrofuran; hexane / -78 - 20 °C

With oxalyl dichloride; tetrabutylammomium bromide; dimethyl sulfoxide; triethylamine; bis(tri-n-butyltin)oxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; benzene;
DOI:10.1016/S0040-4020(97)00240-8