N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide

Base Information

• Chemical Name: N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide
• CAS No.: 1338564-21-8
• Molecular Formula: C₂₆H₂₄Cl₂N₂O
• Molecular Weight: 451.395
• Mol file: 1338564-21-8.mol

Synonyms:N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide

Chemical Property of N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide

There total 3 articles about N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,7-bis(4-chlorophenyl)-2,6-diaza-4,5-benzo-1,4,6-heptatriene (1338564-01-4) + pivaloyl chloride (3282-30-2) → N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide (1338564-21-8)

Guidance literature:

1,7-bis(4-chlorophenyl)-2,6-diaza-4,5-benzo-1,4,6-heptatriene; With potassium tert-butylate; In tetrahydrofuran; at 50 ℃; for 4h;

pivaloyl chloride; In tetrahydrofuran;

With water;

DOI:10.1021/jo201521v

Reference yield:

4-chlorobenzaldehyde (104-88-1) → N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide (1338564-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 18 h / 20 °C / Molecular sieve

2: potassium tert-butylate / tetrahydrofuran / 4 h / 50 °C

With potassium tert-butylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo201521v

Reference yield:

2-amino-1-benzylamine (4403-69-4) → N-(4-chlorobenzyl)-N-(2-p-chlorophenyl-1H-indol-3-yl)-pivalamide (1338564-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 18 h / 20 °C / Molecular sieve

2: potassium tert-butylate / tetrahydrofuran / 4 h / 50 °C

With potassium tert-butylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo201521v

upstream raw materials:

1,7-bis(4-chlorophenyl)-2,6-diaza-4,5-benzo-1,4,6-heptatriene

pivaloyl chloride

4-chlorobenzaldehyde

2-amino-1-benzylamine