tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Base Information

Chemical Name:tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate
CAS No.:158414-49-4
Molecular Formula:C₂₆H₃₅NO₂
Molecular Weight:393.569
Hs Code.:

Synonyms:tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

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Chemical Property of tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

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Technology Process of tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

There total 5 articles about tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 158414-47-2
(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

: 158414-49-4
tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: With potassium hexamethylsilazane; tert-butyl alcohol; In tetrahydrofuran; for 144h; Ambient temperature;
DOI:10.1039/P19940001411

Reference yield:

: 22173-21-3
tert-butyl cyclohex-1-ene-1-carboxylate

: 158414-49-4
tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature

2: 78 percent / potassium bis(trimethylsilyl)amide, tBuOH / tetrahydrofuran / 144 h / Ambient temperature

With 2,6-di-tert-butylphenol; potassium hexamethylsilazane; tert-butyl alcohol; In tetrahydrofuran;
DOI:10.1039/P19940001411

Reference yield:

: 16537-05-6
tert-butyl cyclohexanecarboxylate

: 158414-49-4
tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, I₂, 2.) DBU / 1.) THF, -78 deg C, 1.5 h, 2.) 0 deg C, 1 h, room temperature, 48 h

2: 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature

3: 78 percent / potassium bis(trimethylsilyl)amide, tBuOH / tetrahydrofuran / 144 h / Ambient temperature

With 2,6-di-tert-butylphenol; iodine; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/P19940001411