(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

Base Information

Chemical Name:(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate
CAS No.:158414-47-2
Molecular Formula:C₂₆H₃₅NO₂
Molecular Weight:393.569
Hs Code.:

Synonyms:(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

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Chemical Property of (1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

Chemical Property:

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Technology Process of (1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

There total 3 articles about (1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-89-5
Cyclohexanecarboxylic acid

: 158414-47-2
(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: conc. H₂SO₄ / CH₂Cl₂ / 20 h / -78 deg C to room temperature

2: 1.) LDA, I₂, 2.) DBU / 1.) THF, -78 deg C, 1.5 h, 2.) 0 deg C, 1 h, room temperature, 48 h

3: 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature

With 2,6-di-tert-butylphenol; sulfuric acid; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In dichloromethane;
DOI:10.1039/P19940001411

Reference yield:

: 16537-05-6
tert-butyl cyclohexanecarboxylate

: 158414-47-2
(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, I₂, 2.) DBU / 1.) THF, -78 deg C, 1.5 h, 2.) 0 deg C, 1 h, room temperature, 48 h

2: 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature

With 2,6-di-tert-butylphenol; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide;
DOI:10.1039/P19940001411

Reference yield:

: 22173-21-3
tert-butyl cyclohex-1-ene-1-carboxylate

: lithium N-benzyl-N-((S)-1-phenylethyl)amide

: 158414-47-2
(1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate

Guidance literature:: With 2,6-di-tert-butylphenol; Yield given. Multistep reaction; 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature;
DOI:10.1039/P19940001411